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If you are a marketing professional in charge of your small/medium sized business? (SMB) Search Engine Optimization (SEO) and Inbound marketing, you are not alone.?SMBs spend roughly 22% more on staff salaries to handle SEO & internet marketing ?than do large sized businesses who tend to out-source this activity. For this reason, it is critical that SMB marketers focus carefully. Here are 10 steps to effective marketing online:
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Apr. 17, 2013 ? Neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease.
Using sea snail nerve cells, the scientists reversed memory loss by determining when the cells were primed for learning. The scientists were able to help the cells compensate for memory loss by retraining them through the use of optimized training schedules. Findings of this proof-of-principle study appear in the April 17 issue of The Journal of Neuroscience.
"Although much works remains to be done, we have demonstrated the feasibility of our new strategy to help overcome memory deficits," said John "Jack" Byrne, Ph.D., the study's senior author, as well as director of the W.M. Keck Center for the Neurobiology of Learning and Memory and chairman of the Department of Neurobiology and Anatomy at the UTHealth Medical School.
This latest study builds on Byrne's 2012 investigation that pioneered this memory enhancement strategy. The 2012 study showed a significant increase in long-term memory in healthy sea snails called Aplysia californica, an animal that has a simple nervous system, but with cells having properties similar to other more advanced species including humans.
Yili Zhang, Ph.D., the study's co-lead author and a research scientist at the UTHealth Medical School, has developed a sophisticated mathematical model that can predict when the biochemical processes in the snail's brain are primed for learning.
Her model is based on five training sessions scheduled at different time intervals ranging from 5 to 50 minutes. It can generate 10,000 different schedules and identify the schedule most attuned to optimum learning.
"The logical follow-up question was whether you could use the same strategy to overcome a deficit in memory," Byrne said. "Memory is due to a change in the strength of the connections among neurons. In many diseases associated with memory deficits, the change is blocked."
To test whether their strategy would help with memory loss, Rong-Yu Liu, Ph.D., co-lead author and senior research scientist at the UTHealth Medical School, simulated a brain disorder in a cell culture by taking sensory cells from the sea snails and blocking the activity of a gene that produces a memory protein. This resulted in a significant impairment in the strength of the neurons' connections, which is responsible for long-term memory.
To mimic training sessions, cells were administered a chemical at intervals prescribed by the mathematical model. After five training sessions, which like the earlier study were at irregular intervals, the strength of the connections returned to near normal in the impaired cells.
"This methodology may apply to humans if we can identify the same biochemical processes in humans. Our results suggest a new strategy for treatments of cognitive impairment. Mathematical models might help design therapies that optimize the combination of training protocols with traditional drug treatments," Byrne said.
He added, "Combining these two could enhance the effectiveness of the latter while compensating at least in part for any limitations or undesirable side effects of drugs. These two approaches are likely to be more effective together than separately and may have broad generalities in treating individuals with learning and memory deficits."
Other co-authors from the UTHealth Medical School included: Douglas A. Baxter, Ph.D., professor; Paul Smolen, Ph.D., assistant professor; and Len Cleary, Ph.D., professor.
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TOKYO (AP) ? Japanese readers are flocking to buy Haruki Murakami's latest novel, even though almost nothing has been disclosed about the book by one of the nation's most respected and commercially successful writers.
The novel that went on sale Friday is the first in three years for the writer frequently mentioned as a Nobel Prize contender. It's available only in Japanese for now.
Publisher Bungeishunju said first printing totals half a million copies for "Colorless Tsukuru Tazaki and the Year of His Pilgrimage." The original title reads just as mysteriously.
"We did not want to give any preconceptions to the reader," said Tomoya Tanimura of Bungeishunju, which has set up a special online site that has little more than the title and that Murakami is the author.
The secrecy seemed to matter little to his fans.
"I want to savor reading this book. I love the language of Haruki Murakami, his special sense of Japanese. I am so excited," said Yu Wada, a Tokyo translator and among the 20,000 people who ordered the book in advance through online retailer Amazon.
The orders at Amazon are outpacing Murakami's last "1Q84," a three-part Orwellian novel, which was also a hit, according to Bungeishunju.
Wada has only read the first few pages but is satisfied. It is dark, she says, and it starts out with a character who looks back on his younger days, when he "lived thinking about practically nothing else than dying."
Murakami's internationally known works include "Norwegian Wood" and "The Wind-Up Bird Chronicle." An accomplished translator of American literature, Murakami counts among his influences F. Scott Fitzgerald and Raymond Chandler. He taught at Princeton University in the early 1990s.
Murakami is a prolific non-fiction writer as well, and documented the victims of a cult's sarin-gas attack on Tokyo's subway in 1995.
Murakami has also become an aggressive critic of Japan's pro-nuclear policies since the 2011 Fukushima disaster.
"Norwegian Wood," was made into a 2010 movie, directed by Tran Anh Hung, a poetic coming-of-age love story exploring the themes of sanity and suicide in the backdrop of the late 1960s.
Murakami's reticence and reclusiveness have enhanced his glamour. And, true to form, Murakami has revealed little about his latest book, except for a brief statement.
"I started out writing a short story, but as I was working on it, it got longer naturally. I've rarely experienced this ? maybe not since 'Norwegian Wood,'" he said.
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Follow Yuri Kageyama on Twitter at www.twitter.com/yurikageyama
Source: http://news.yahoo.com/japanese-flock-murakami-book-mystery-title-053649511.html
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You might say the day is never really done in consumer technology news. Your workday, however, hopefully draws to a close at some point. This is the Daily Roundup on Engadget, a quick peek back at the top headlines for the past 24 hours -- all handpicked by the editors here at the site. Click on through the break, and enjoy.
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FILE - In this March 15, 2013, file photo the Senate Minority Leader, Republican Mitch McConnell of Kentucky, points to a 7-foot stack of ?Obamacare? regulations to underscore his disdain during the 40th annual Conservative Political Action Conference in National Harbor, Md. McConnell said Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. ?I agree that it will be a big issue in 2014,? he said. ?I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it.? (AP Photo/Manuel Balce Ceneta, File)
FILE - In this March 15, 2013, file photo the Senate Minority Leader, Republican Mitch McConnell of Kentucky, points to a 7-foot stack of ?Obamacare? regulations to underscore his disdain during the 40th annual Conservative Political Action Conference in National Harbor, Md. McConnell said Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. ?I agree that it will be a big issue in 2014,? he said. ?I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it.? (AP Photo/Manuel Balce Ceneta, File)
Charts profile the uninsured
FILE - In this Dec. 1, 2010, file photo Rep. Jan Schakowsky, D-Ill., speaks during a Debt Commission meeting on Capitol Hill in Washington. In 2013 with a nation still split over President Barack Obama's healthcare overhaul Schakowsky, who has long supported coverage for the uninsured, is predicting vindication for the Affordable Care Act once people see how the program really works. ?It?s harder to sell what is a pretty new idea for Americans while it is still in the abstract,? she said. ?I think as people experience it, they?re going to love it, much like Medicare.? (AP Photo/Alex Brandon, File)
FILE ? In this June 29, 2012 file photo front pages of the days' newspaper front pages are displayed at the Newseum in Washington, after the previous day's Supreme Court ruling to uphold President Barack Obama's health care law. With a nation still split over the affordable care act, and in an effort to convince millions of average Americans that one of the most common complex and controversial programs devised by government may actually be good for them the administration has turned to the science of mass marketing for help in understanding the lives of uninsured people, hoping to craft winning pitches for a surprisingly varied group in society. (AP Photo/David Goldman, File)
FILE ? In this Aug. 31, 2009, file photo supporters on both sides of the health care reform issue argue in Skokie, Ill., outside a town hall meeting held by U.S. Rep. Jan Schakowsky, who represents Chicago. With a nation still split over the Affordable Care Act Schakowsky, a long-time supporter of coverage for the insured, is predicting vindication for the health overhaul legislation once people see how the program really works. ?It?s harder to sell what is a pretty new idea for Americans while it is still in the abstract,? she said. ?I think as people experience it, they?re going to love it, much like Medicare.? (AP Photo/ Jim Prisching, File)
WASHINGTON (AP) ? How do you convince millions of average Americans that one of the most complex and controversial programs devised by government may actually be a good deal for them?
With the nation still split over President Barack Obama's health care law, the administration has turned to the science of mass marketing for help in understanding the lives of uninsured people, hoping to craft winning pitches for a surprisingly varied group in society.
The law's supporters will have to make the sale in the run-up to an election ? the 2014 midterms. Already Republicans are hoping for an "Obamacare" flop that helps them gain control of the Senate, while Democrats are eager for the public to finally embrace the Affordable Care Act, bringing political deliverance.
It turns out America's more than 48 million uninsured people are no monolithic mass. A marketing analysis posted online by the federal Health and Human Services Department reveals six distinct groups, three of which appear critical to the success or failure of the program.
They're the "Healthy & Young," comprising 48 percent of the uninsured, the "Sick, Active & Worried," (29 percent of the uninsured), and the "Passive & Unengaged" (15 percent).
The Healthy & Young take good health for granted, are tech-savvy, and have "low motivation to enroll." The Sick, Active & Worried are mostly Generation X and baby boomers, active seekers of health care information and worried about costs. The Passive & Unengaged group is mostly 49 and older, "lives for today," and doesn't understand much about health insurance.
The challenge for the administration is obvious: signing up lots of the Healthy & Young, as well as the Passive & Unengaged, to offset the higher costs of covering the sick and worried.
Uninsured middle-class Americans will be able to sign up for subsidized private health plans through new insurance markets in their states starting Oct.1. Low-income uninsured people will be steered to safety net programs like Medicaid.
"The goal here is to get as many people enrolled as possible," Gary Cohen, the HHS official overseeing the rollout of the law, told insurers at a recent industry conference. Partly for that reason the first open enrollment period will continue until March 31, 2014.
Coverage under the law takes effect Jan. 1. That's also when the legal requirement that most Americans carry health insurance goes into force. Insurance companies will be barred from turning the sick away or charging them more.
The new law is mainly geared to the uninsured and to people who buy coverage directly from insurance companies. Most Americans in employer plans are not expected to see major changes.
Administration officials say they see an opportunity to change the national debate about health care. They want to get away from shouting matches about the role of government and start millions of practical conversations about new benefits that can help families and individuals.
The HHS marketing materials reveal some barriers to getting the uninsured to embrace the law.
The Healthy & Young lead busy lives and tend to be procrastinators. Plus, why would they need health insurance if they're full of vigor? The Passive & Unengaged fear the unknown and have difficulty navigating the health care system. The Sick, Active & Worried dread making wrong decisions.
Marketing for the new system will start this summer, going into high gear during the fall after premiums and other plan information becomes public.
There's already widespread concern that the new coverage costs too much, because of a combination of sicker people joining the pool and federal requirements that insurers offer more robust benefits. A recent study by the Society of Actuaries forecast sticker shock, estimating that insurers will have to pay an average of 32 percent more for medical claims on individual health policies.
The administration says such studies are misleading because they don't take into account parts of the law that offset costs to individuals and insurance companies, along with other provisions that promote competition and increase oversight of insurance rates.
Rep. Jan Schakowsky, D-Ill., who has long supported coverage for the uninsured, is predicting vindication for Obama once people see how the program really works.
"It's harder to sell what is a pretty new idea for Americans while it is still in the abstract," said Schakowsky, who represents Chicago. "I think as people experience it, they're going to love it, much like Medicare."
That will put wind in the sails of Democratic candidates. "I think it's going to be a very popular feature as far as the American way of life before too long," Schakowsky added.
But Senate Republican Leader Mitch McConnell of Kentucky says Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. McConnell had his picture taken next to a 7-foot stack of "Obamacare" regulations recently to underscore his disdain.
"I agree that it will be a big issue in 2014," said McConnell. "I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it."
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Online:
HHS marketing study ? http://tinyurl.com/aycgowc
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