Thursday, April 25, 2013

Mild blast injury causes molecular changes in brain akin to Alzheimer

Apr. 24, 2013 ? A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease.

Their findings were recently reported in the online version of the Journal of Neurotrauma.

Blast-induced traumatic brain injury (TBI) has become an important issue in combat casualty care, said senior investigator Patrick Kochanek, M.D., professor and vice chair of critical care medicine and director of the Safar Center for Resuscitation Research at Pitt. In many cases of mild TBI, MRI scans and other conventional imaging technology do not show overt damage to the brain.

"Our research reveals that despite the lack of a lot of obvious neuronal death, there is a lot of molecular madness going on in the brain after a blast exposure," Dr. Kochanek said. "Even subtle injuries resulted in significant alterations of brain chemistry."

The research team developed a rat model to examine whether mild blast exposure in a device called a shock tube caused any changes in the brain even if there was no indication of direct cell death, such as bleeding. Brain tissues of rats exposed to blast and to a sham procedure were tested two and 24 hours after the injury.

Gene activity patterns, which shifted over time, resembled patterns seen in neurodegenerative diseases, particularly Alzheimer's, Dr. Kochanek noted. Markers of inflammation and oxidative stress, which reflects disruptions of cell signaling, were elevated, but there was no indication of energy failure that would be seen with poor tissue oxygenation.

"It appears that although the neurons don't die after a mild injury, they do sustain damage," he said. "It remains to be seen what multiple exposures, meaning repeat concussions, do to the brain over the long term."

Co-authors include researchers from the Safar Center for Resuscitation Research and the University of Pittsburgh School of Medicine; University of California, San Diego; ORA Inc., of Fredericksburg, Va.; Walter Reed Army Institute of ResearchDyn-FX Consulting Ltd, Amherstburg, ON; Uniformed Services University of the Health Sciences, Bethesda, MD; and Integrated Services Group, Inc., Potomac, MD.

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The above story is reprinted from materials provided by University of Pittsburgh Schools of the Health Sciences.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Patrick M. Kochanek, C. Edward Dixon, David K. Shellington, Samuel S. Shin, Hulya Bayir, Edwin Jackson, Valerian Kagan, Hong Qu Yan, Peter V Swauger, Steven Parks, David V. Ritzel, Richard A Bauman, Robert Clark, Robert H. Garman, Faris Bandak, Geoffrey S.F. Ling, Larry W. Jenkins. Screening of Biochemical and Molecular Mechanisms of Secondary Injury and Repair in the Brain after Experimental Blast-Induced Traumatic Brain Injury in Rats. Journal of Neurotrauma, 2013; : 130317122119004 DOI: 10.1089/neu.2013.2862

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/jLqhtFJvKNU/130424103128.htm

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Wednesday, April 24, 2013

Groupon Adds Global Search To iPhone, Android, Now Supports Android Tablets To Sharpen Up For Yelp, Foursquare Rivalry

Groupon global searchGroupon's VP of mobile, David Katz, says that it has been "business as usual" at the daily deals company since the dramatic departure of founder/CEO Andrew Mason. "We're still just focused on shipping new stuff," Katz told TechCrunch in an interview. Today, that includes news of updates to Groupon's iPhone and Android apps: it is adding a universal search feature that will let consumers use the apps to search for Marketplace deals that are available nearby, covering not just local discounts that are time-sensitive but rolling offers that are not.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/QSKAnOF22Cw/

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Friday, April 19, 2013

Effective Online Marketing for SMBs | Schuler Design

Effective Online Marketing for SMBs | Schuler Design Effective Online Marketing for SMBs

If you are a marketing professional in charge of your small/medium sized business? (SMB) Search Engine Optimization (SEO) and Inbound marketing, you are not alone.?SMBs spend roughly 22% more on staff salaries to handle SEO & internet marketing ?than do large sized businesses who tend to out-source this activity. For this reason, it is critical that SMB marketers focus carefully. Here are 10 steps to effective marketing online:

  1. The Importance of Google?? 80% of all searches being conducted thru Google, so it is crucial to focus primarily?on this search engine. Yahoo and Bing aren?t as important but still are an important part of search engine marketing.
  2. Pick the Right Keywords & Phrases?? Choose keywords that are relevant to your business and rank easily. Look for multi-word phrases or ?long-tail keywords? as they are usually less competitive
  3. Social Media?? Focus on the top three social media venues: Twitter, Facebook, and LinkedIn. Remember, ?be real? and ?be there? to help the community rather than to push products.
  4. Effective Landing Pages?- Everything that has been done to draw qualified traffic to a site, from improving SEO, to generating great content comes to a head in the landing page. Leads should be confronted with an inescapable case for them to leave their carefully guarded personal information on the form. Having one offer, recapping benefits, and a short form are all key.
  5. Calls-to-Action?? A landing page will not be effective without obvious calls to action. It?s important to provide something of value that solves a problem for visitors ?in exchange for their contact information. Even if your audience isn?t ready to purchase they may be willing offer their information in exchange for more insight into your product or service.
  6. Content is King?- Prospects are more likely to buy from you if you are a thought leader, so establish yourself as one by creating extraordinarily helpful content. Take decisive action to ensure prospective customers are attracted to your site as a place to find answers.
  7. Charity is Also King?? Another key part to attracting customers is your generosity in giving away information, access to tools, etc., which also earns you inbound links which improves your search engine rankings.
  8. Follow Ups?? ?Thank you? emails go a long way to generating future leads. Be sure to include additional free offerings? this is a free opportunity to keep touch with a lead.
  9. Tracking Analytics?? Effective Inbound Marketing is all about experimentation. Select a strategy based on experience with customers and industry to get people to both visit and convert on the website. But anticipate that initial assumptions about keywords, or what it takes to get traffic to convert will not be right (or not right enough) and changes will need to be made. For this reason, it is essential to have a complete internet analysis tool-suite to help figure out what?s working and what?s not.

For more information on how we can help with your Online Marketing efforts contact us now.

This entry was posted on Thursday, April 18th, 2013 at 3:00 pm

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Copyright ? 2013 Schuler Design, LLC. All Rights Reserved.

Source: http://www.schuler-design.com/2013/04/effective-online-marketing-for-smbs/

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Scientists reverse memory loss in animal brain cells

Apr. 17, 2013 ? Neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease.

Using sea snail nerve cells, the scientists reversed memory loss by determining when the cells were primed for learning. The scientists were able to help the cells compensate for memory loss by retraining them through the use of optimized training schedules. Findings of this proof-of-principle study appear in the April 17 issue of The Journal of Neuroscience.

"Although much works remains to be done, we have demonstrated the feasibility of our new strategy to help overcome memory deficits," said John "Jack" Byrne, Ph.D., the study's senior author, as well as director of the W.M. Keck Center for the Neurobiology of Learning and Memory and chairman of the Department of Neurobiology and Anatomy at the UTHealth Medical School.

This latest study builds on Byrne's 2012 investigation that pioneered this memory enhancement strategy. The 2012 study showed a significant increase in long-term memory in healthy sea snails called Aplysia californica, an animal that has a simple nervous system, but with cells having properties similar to other more advanced species including humans.

Yili Zhang, Ph.D., the study's co-lead author and a research scientist at the UTHealth Medical School, has developed a sophisticated mathematical model that can predict when the biochemical processes in the snail's brain are primed for learning.

Her model is based on five training sessions scheduled at different time intervals ranging from 5 to 50 minutes. It can generate 10,000 different schedules and identify the schedule most attuned to optimum learning.

"The logical follow-up question was whether you could use the same strategy to overcome a deficit in memory," Byrne said. "Memory is due to a change in the strength of the connections among neurons. In many diseases associated with memory deficits, the change is blocked."

To test whether their strategy would help with memory loss, Rong-Yu Liu, Ph.D., co-lead author and senior research scientist at the UTHealth Medical School, simulated a brain disorder in a cell culture by taking sensory cells from the sea snails and blocking the activity of a gene that produces a memory protein. This resulted in a significant impairment in the strength of the neurons' connections, which is responsible for long-term memory.

To mimic training sessions, cells were administered a chemical at intervals prescribed by the mathematical model. After five training sessions, which like the earlier study were at irregular intervals, the strength of the connections returned to near normal in the impaired cells.

"This methodology may apply to humans if we can identify the same biochemical processes in humans. Our results suggest a new strategy for treatments of cognitive impairment. Mathematical models might help design therapies that optimize the combination of training protocols with traditional drug treatments," Byrne said.

He added, "Combining these two could enhance the effectiveness of the latter while compensating at least in part for any limitations or undesirable side effects of drugs. These two approaches are likely to be more effective together than separately and may have broad generalities in treating individuals with learning and memory deficits."

Other co-authors from the UTHealth Medical School included: Douglas A. Baxter, Ph.D., professor; Paul Smolen, Ph.D., assistant professor; and Len Cleary, Ph.D., professor.

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The above story is reprinted from materials provided by University of Texas Health Science Center at Houston.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. R.-Y. Liu, Y. Zhang, D. A. Baxter, P. Smolen, L. J. Cleary, J. H. Byrne. Deficit in Long-Term Synaptic Plasticity Is Rescued by a Computationally Predicted Stimulus Protocol. Journal of Neuroscience, 2013; 33 (16): 6944 DOI: 10.1523/JNEUROSCI.0643-13.2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/ehxTz4xzIJQ/130417164451.htm

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Friday, April 12, 2013

Japanese flock to Murakami book with mystery title

TOKYO (AP) ? Japanese readers are flocking to buy Haruki Murakami's latest novel, even though almost nothing has been disclosed about the book by one of the nation's most respected and commercially successful writers.

The novel that went on sale Friday is the first in three years for the writer frequently mentioned as a Nobel Prize contender. It's available only in Japanese for now.

Publisher Bungeishunju said first printing totals half a million copies for "Colorless Tsukuru Tazaki and the Year of His Pilgrimage." The original title reads just as mysteriously.

"We did not want to give any preconceptions to the reader," said Tomoya Tanimura of Bungeishunju, which has set up a special online site that has little more than the title and that Murakami is the author.

The secrecy seemed to matter little to his fans.

"I want to savor reading this book. I love the language of Haruki Murakami, his special sense of Japanese. I am so excited," said Yu Wada, a Tokyo translator and among the 20,000 people who ordered the book in advance through online retailer Amazon.

The orders at Amazon are outpacing Murakami's last "1Q84," a three-part Orwellian novel, which was also a hit, according to Bungeishunju.

Wada has only read the first few pages but is satisfied. It is dark, she says, and it starts out with a character who looks back on his younger days, when he "lived thinking about practically nothing else than dying."

Murakami's internationally known works include "Norwegian Wood" and "The Wind-Up Bird Chronicle." An accomplished translator of American literature, Murakami counts among his influences F. Scott Fitzgerald and Raymond Chandler. He taught at Princeton University in the early 1990s.

Murakami is a prolific non-fiction writer as well, and documented the victims of a cult's sarin-gas attack on Tokyo's subway in 1995.

Murakami has also become an aggressive critic of Japan's pro-nuclear policies since the 2011 Fukushima disaster.

"Norwegian Wood," was made into a 2010 movie, directed by Tran Anh Hung, a poetic coming-of-age love story exploring the themes of sanity and suicide in the backdrop of the late 1960s.

Murakami's reticence and reclusiveness have enhanced his glamour. And, true to form, Murakami has revealed little about his latest book, except for a brief statement.

"I started out writing a short story, but as I was working on it, it got longer naturally. I've rarely experienced this ? maybe not since 'Norwegian Wood,'" he said.

___

Follow Yuri Kageyama on Twitter at www.twitter.com/yurikageyama

Source: http://news.yahoo.com/japanese-flock-murakami-book-mystery-title-053649511.html

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Video: Top Investment Strategies From New 'Squawk Master'

Sorry, Readability was unable to parse this page for content.

Source: http://www.nbcnews.com/video/cnbc/51504121/

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Tuesday, April 2, 2013

The Daily Roundup for 04.01.2013

DNP The Daily RoundUp

You might say the day is never really done in consumer technology news. Your workday, however, hopefully draws to a close at some point. This is the Daily Roundup on Engadget, a quick peek back at the top headlines for the past 24 hours -- all handpicked by the editors here at the site. Click on through the break, and enjoy.

Comments

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Rf7GAsMibbQ/

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Monday, April 1, 2013

Marketing studies help craft health overhaul pitch

FILE - In this March 15, 2013, file photo the Senate Minority Leader, Republican Mitch McConnell of Kentucky, points to a 7-foot stack of ?Obamacare? regulations to underscore his disdain during the 40th annual Conservative Political Action Conference in National Harbor, Md. McConnell said Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. ?I agree that it will be a big issue in 2014,? he said. ?I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it.? (AP Photo/Manuel Balce Ceneta, File)

FILE - In this March 15, 2013, file photo the Senate Minority Leader, Republican Mitch McConnell of Kentucky, points to a 7-foot stack of ?Obamacare? regulations to underscore his disdain during the 40th annual Conservative Political Action Conference in National Harbor, Md. McConnell said Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. ?I agree that it will be a big issue in 2014,? he said. ?I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it.? (AP Photo/Manuel Balce Ceneta, File)

Charts profile the uninsured

FILE - In this Dec. 1, 2010, file photo Rep. Jan Schakowsky, D-Ill., speaks during a Debt Commission meeting on Capitol Hill in Washington. In 2013 with a nation still split over President Barack Obama's healthcare overhaul Schakowsky, who has long supported coverage for the uninsured, is predicting vindication for the Affordable Care Act once people see how the program really works. ?It?s harder to sell what is a pretty new idea for Americans while it is still in the abstract,? she said. ?I think as people experience it, they?re going to love it, much like Medicare.? (AP Photo/Alex Brandon, File)

FILE ? In this June 29, 2012 file photo front pages of the days' newspaper front pages are displayed at the Newseum in Washington, after the previous day's Supreme Court ruling to uphold President Barack Obama's health care law. With a nation still split over the affordable care act, and in an effort to convince millions of average Americans that one of the most common complex and controversial programs devised by government may actually be good for them the administration has turned to the science of mass marketing for help in understanding the lives of uninsured people, hoping to craft winning pitches for a surprisingly varied group in society. (AP Photo/David Goldman, File)

FILE ? In this Aug. 31, 2009, file photo supporters on both sides of the health care reform issue argue in Skokie, Ill., outside a town hall meeting held by U.S. Rep. Jan Schakowsky, who represents Chicago. With a nation still split over the Affordable Care Act Schakowsky, a long-time supporter of coverage for the insured, is predicting vindication for the health overhaul legislation once people see how the program really works. ?It?s harder to sell what is a pretty new idea for Americans while it is still in the abstract,? she said. ?I think as people experience it, they?re going to love it, much like Medicare.? (AP Photo/ Jim Prisching, File)

(AP) ? How do you convince millions of average Americans that one of the most complex and controversial programs devised by government may actually be a good deal for them?

With the nation still split over President Barack Obama's health care law, the administration has turned to the science of mass marketing for help in understanding the lives of uninsured people, hoping to craft winning pitches for a surprisingly varied group in society.

The law's supporters will have to make the sale in the run-up to an election ? the 2014 midterms. Already Republicans are hoping for an "Obamacare" flop that helps them gain control of the Senate, while Democrats are eager for the public to finally embrace the Affordable Care Act, bringing political deliverance.

It turns out America's more than 48 million uninsured people are no monolithic mass. A marketing analysis posted online by the federal Health and Human Services Department reveals six distinct groups, three of which appear critical to the success or failure of the program.

They're the "Healthy & Young," comprising 48 percent of the uninsured, the "Sick, Active & Worried," (29 percent of the uninsured), and the "Passive & Unengaged" (15 percent).

The Healthy & Young take good health for granted, are tech-savvy, and have "low motivation to enroll." The Sick, Active & Worried are mostly Generation X and baby boomers, active seekers of health care information and worried about costs. The Passive & Unengaged group is mostly 49 and older, "lives for today," and doesn't understand much about health insurance.

The challenge for the administration is obvious: signing up lots of the Healthy & Young, as well as the Passive & Unengaged, to offset the higher costs of covering the sick and worried.

Uninsured middle-class Americans will be able to sign up for subsidized private health plans through new insurance markets in their states starting Oct.1. Low-income uninsured people will be steered to safety net programs like Medicaid.

"The goal here is to get as many people enrolled as possible," Gary Cohen, the HHS official overseeing the rollout of the law, told insurers at a recent industry conference. Partly for that reason the first open enrollment period will continue until March 31, 2014.

Coverage under the law takes effect Jan. 1. That's also when the legal requirement that most Americans carry health insurance goes into force. Insurance companies will be barred from turning the sick away or charging them more.

The new law is mainly geared to the uninsured and to people who buy coverage directly from insurance companies. Most Americans in employer plans are not expected to see major changes.

Administration officials say they see an opportunity to change the national debate about health care. They want to get away from shouting matches about the role of government and start millions of practical conversations about new benefits that can help families and individuals.

The HHS marketing materials reveal some barriers to getting the uninsured to embrace the law.

The Healthy & Young lead busy lives and tend to be procrastinators. Plus, why would they need health insurance if they're full of vigor? The Passive & Unengaged fear the unknown and have difficulty navigating the health care system. The Sick, Active & Worried dread making wrong decisions.

Marketing for the new system will start this summer, going into high gear during the fall after premiums and other plan information becomes public.

There's already widespread concern that the new coverage costs too much, because of a combination of sicker people joining the pool and federal requirements that insurers offer more robust benefits. A recent study by the Society of Actuaries forecast sticker shock, estimating that insurers will have to pay an average of 32 percent more for medical claims on individual health policies.

The administration says such studies are misleading because they don't take into account parts of the law that offset costs to individuals and insurance companies, along with other provisions that promote competition and increase oversight of insurance rates.

Rep. Jan Schakowsky, D-Ill., who has long supported coverage for the uninsured, is predicting vindication for Obama once people see how the program really works.

"It's harder to sell what is a pretty new idea for Americans while it is still in the abstract," said Schakowsky, who represents Chicago. "I think as people experience it, they're going to love it, much like Medicare."

That will put wind in the sails of Democratic candidates. "I think it's going to be a very popular feature as far as the American way of life before too long," Schakowsky added.

But Senate Republican Leader Mitch McConnell of Kentucky says Democrats have been predicting for years that Americans would learn to love the health care overhaul and that has not happened. McConnell had his picture taken next to a 7-foot stack of "Obamacare" regulations recently to underscore his disdain.

"I agree that it will be a big issue in 2014," said McConnell. "I think it will be an albatross around the neck of every Democrat who voted for it. They are going to be running away from it, not toward it."

___

Online:

HHS marketing study ? http://tinyurl.com/aycgowc

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-31-Health%20Overhaul-Crafting%20the%20Pitch/id-99fea257bce0450685a3a1f2f7d17948

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Saturday, March 30, 2013

Obesity on the menu' for kids, group says | WTKR.com

(CNN) ? Fried chicken fingers, hamburgers, French fries and sugary sodas dominate children?s menus in most chain restaurants, and most kids? meals fall short of meeting basic nutritional standards, a nonprofit health advocacy group said Thursday.

Some 97% of nearly 3,500 kids? meals analyzed don?t meet basic nutritional standards, the Center for Science in the Public Interest said in its report ?Kids? Meals: Obesity on the Menu.?

What?s more, 91% don?t meet the National Restaurant Association?s own nutritional guidelines for its Kids LiveWell program, a voluntary program for restaurant owners, according to the report.

?Given that 1 out of 3 American children are overweight or obese, it?s pretty stunning that the top chain restaurants are still serving up the same old fried chicken nuggets, burgers, macaroni and cheese, fries and soda,? said Margo Wootan, director of nutrition policy at the CSPI and lead author of the report.

The worst offender: Applebee?s grilled cheese sandwich on sourdough bread with fries and 2% chocolate milk. The meal came in at a whopping 1,200 calories and 21 grams of saturated fat.

That?s followed by Chili?s pepperoni pizza meal with homestyle fries and a soda, which packs 1,120 calories, and Dairy Queen?s fried chicken strip meal with fries, a slushy drink and an ice cream bar, with 1,030 calories.

The CSPI nutritional standard was no more than 430 calories per meal, while the Kids LiveWell standard is 600 calories. Standards for both groups included no more than 770 milligrams of sodium per meal.

Nineteen restaurant chains offering kids meals, or 56%, fail to offer any meals meeting CSPI?s standards, the report says, and nine do not have one meal meeting the Kids LiveWell standards.

?It?s as if the restaurant industry hasn?t heard there is an obesity epidemic,? Wootan said.

In response to the report, Applebee?s and Chili?s pointed out that while one meal may have been singled out, they do offer healthy options for children.

?Although this report focuses on one sandwich from our children?s menu, the full Applebee?s children?s menu provides many options that are significantly lower in calories, fat and sodium? and meet the Kids LiveWell standards, said spokesman Kevin Mortesen. The chain?s grilled chicken sandwich meal for kids, with steamed broccoli and apple or grape juice, totals only 355 calories, he said.

?We know Applebee?s best serves our guests by providing a wide selection of dishes, and we?ll continue to do so by expanding the number of options for kids by the end of this year.?

Chili?s says it offers a number of lower-calorie, lower-sodium and low-fat options on both its adult and Pepper Pals child menus, and that guests may customize and modify their orders ? substituting side items, for instance.

?We do our part on our Pepper Pals menu to meet these requirements (for a well-balanced meal) by offering choices, including grilled chicken, salad with low-fat ranch dressing, fresh pineapples, steamed broccoli and celery sticks,? the company said in a statement.

Chili?s was an ?inaugural partner? of the National Restaurant Association?s Kids LiveWell program, according to the statement, and ?continues to support this organization which empowers parents to make informed decisions about their children?s meals as part of maintaining a healthy lifestyle.?

The National Restaurant Association, meanwhile, touted the program. Joy Dubost, the association?s director of nutrition and healthy living, called Kids LiveWell ?a first-of-its-kind, voluntary initiative that helps parents and children select healthful menu options when dining out at nearly 40,000 locations nationwide.

?The program, now with more than 120 restaurant brands, has achieved significant momentum in just 18 short months ? participating restaurants offer and promote healthful meals for children,? Dubost said.

Dairy Queen did not immediately respond to a CNN request for comment on the report.

The CSPI describes itself as a Washington-based nonprofit health advocacy group focusing on nutrition and food safety. Of the kids? meals it analyzed, 86% contained more than 430 calories, and 50% have more than 600 calories, the report says. About two-thirds ? 66% ? exceeded the sodium standard.

The federal government?s Dietary Guidelines for Americans states that children ages 4 to 10 consume between 400 and 670 calories at each meal, depending on their age, gender and physical activity levels.

While some chains offer non-soda and fruit options, ?soft drinks and fried potatoes are still more common options on children?s menus,?? according to the report. The CSPI recommendations include offering more fruit and vegetable options and making those the default side dishes with every children?s meal.

However, the news isn?t all bad, according to the report. All eight of Subway?s Fresh Fit for Kids meal combinations met CSPI?s nutrition criteria.

The chain also was lauded for not offering sugary drinks as an option with kids? meals, instead including low-fat milk or bottled water and apple slices with its child-sized subs. However the group recommended that Subway increase the whole-grain content of its breads and continue to lower sodium.

The best Subway option: a kids? roast beef sub, apple slices and 1% milk, which comes in at 395 calories.

Other healthy choices: Burger King?s oatmeal, IHOP?s whole wheat blueberry pancakes, Outback Steakhouse?s kids sirloin with apples and grapes, and Olive Garden?s cheese ravioli with broccoli and orange juice.

?Four years ago we found that only 1% of kids? meals at the top chain restaurants were healthy, and now 3% are healthy,? Wootan said. ?So there is a tiny bit of improvement, but it?s very, very small.?

Sodium rates also have shown improvement, she said. In 2008, only 15% of restaurant meals met the sodium standard; now 35% do.

The bottom line, she said: There?s a lot of work to do.

?In order for parents to feed their children healthfully, restaurants need to help,? Wootan said. The group encourages participation in the Kids LiveWell program, and says restaurants should offer more whole grains and get rid of soda and other sugary drinks.

?We know they can do it, because some are already doing it,? she said.

Source: http://wtkr.com/2013/03/28/obesity-on-the-menu-for-kids-group-says/

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Spy who foiled jet bomb plot to be Britain's intelligence chief

By Peter Griffiths

LONDON (Reuters) - A British counterspy who helped to thwart an al Qaeda plot to blow up planes with explosives hidden in soft drink bottles and led the response to the 2005 London transport bombings will be the new head of Britain's domestic intelligence agency, the U.K. government said on Thursday.

Andrew Parker has three decades' experience at the Security Service, known as MI5, countering Islamist militants, violent Irish republicans and organized criminals. He has been deputy chief since 2007, and once served as a British security liaison in the United States.

The 50-year-old, a keen birdwatcher and wildlife photographer, will be in charge of 3,800 staff investigating threats ranging from bomb plots and the spread of weapons of mass destruction to espionage and cyber attacks.

One of his first tasks will be to protect U.S. President Barack Obama, British Prime Minister David Cameron and other world leaders at the Group of Eight summit in Northern Ireland in June.

As Britain hosted the annual G8 meeting in 2005 in Gleneagles, Scotland, four suicide bombers killed 52 underground and bus commuters in London in coordinated attacks. Parker was in charge of the agency's response to the bombings and oversaw a significant expansion of its role.

Parker, who led MI5 teams that disrupted a 2006 conspiracy to attack several passenger jets with bombs hidden in soft drink bottles, said it was a "great honor" to be made head of the agency, also known as the Security Service.

"I look forward to leading the Service through its next chapter," he said in a statement.

The bespectacled father-of-two will replace the current head, Jonathan Evans, when he steps down in April after six years in the job during which Britain suffered no significant attacks.

Once so publicity-shy it officially did not exist and its director's identity was kept secret, MI5 now has a website which discusses its responsibilities and activities. On Thursday, the website posted an official biography of its new chief.

ENGLISH-SPEAKING MILITANTS

Counter-terrorism operations will remain at or near the top of MI5's priority assignments from the moment Parker takes the agency's helm.

European counter-terrorism officials have for years been concerned about British citizens and residents who travel to hot spots in the Middle East or South Asia, either to be indoctrinated and trained in militant ideology and guerrilla tactics before returning home, or to fight with local militants.

British authorities estimate that every year, 400,000 people travel from the U.K. to Pakistan. While only a tiny proportion of these travelers have any interest in militant activities, even a small number of recruits can cause disproportionate chaos, as occurred in London on July 7, 2005.

Among the hot spots which currently concern British and other European authorities most are Syria and Somalia. While travel by would-be militants to Somalia from Britain is relatively easy to trace, tracking movements of would-be recruits to anti-Assad forces in Syria is more difficult, since much such travel can be completed unobtrusively and over land.

European counter-terrorism officials have estimated that as many as 60 to 70 English-speaking militants with British citizenship or residence are currently fighting with rebel forces in Syria. There is concern that many of them may have joined up with al-Nusrah, an Islamist faction which U.S. officials describe as a front for Al Qaeda in Iraq.

CYBER-ESPIONAGE

While the signals intelligence agency Government Communications Headquarters (GCHQ) is Britain's main cyber-security unit, under Parker's leadership MI5 will be responsible for investigating specific cases of state-sponsored cyber-espionage directed against such critical targets as gas and power grids and defense and pharmaceutical manufacturers.

Based on what it learns from such cases and in consultation with other agencies, MI5 also advises potential targets on how to protect themselves against cyber attacks. MI5 does not have responsibility for cyber crime or dealing with hackers.

As part of its role in cyber security, Parker's agency will have to anticipate how to keep security measures ahead of technological innovation. And it will have to do so in an environment where greater productivity will have to be extracted from shrinking resources, including budgets.

(Additional reporting by Mark Hosenball in Washington; Editing by Pravin Char and Todd Eastham)

Source: http://news.yahoo.com/spy-foiled-jet-bomb-plot-britains-mi5-intelligence-201926665.html

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Thursday, March 28, 2013

Presidential Madness (Rounds 3 & 4): Secretary of war and defense

United_States_Department_of_Defense_Seal.svgOur two-week contest to pick the best presidential Cabinet ever continues with two matchups involving the men who led America through war and peace.

Join Presidential Madness!

At Constitution Daily, madness in March doesn?t just apply to the NCAA?it?s also an awesome excuse to give the bracket treatment to the executive branch of government. This year, it?s all about the presidential Cabinet.

Get into Presidential Madness by downloading a bracket [PDF] and predicting who you think will make it to the finals as best Cabinet member of all time. Check in and vote each day at Constitution Daily for the latest round of polling.

Round 3: Secretary of war (pre-WWII)

The War Department predated the Constitution, and its leaders headed the Army and were third in line to the presidency. It was replaced by the Defense Department after World War II.

1. John C. Calhoun. Served 1817 ? 1825. As James Monroe?s secretary of war, Calhoun tried to modernize the military and expand its ability to function nationally.

2. Edwin Stanton. Served 1862 ? 1869. Stanton managed the Civil War effort for President Abraham Lincoln, and his later feud with Andrew Johnson led to Johnson?s impeachment.

3. William Howard Taft. Served 1904 ? 1908. Taft served President Theodore Roosevelt in important matters in Panama and the Philippines, and as a de facto vice president.

4. Henry Stimson. Served 1911 ? 1913, 1940?? 1945. Stimson had two tours at the War Department, including managing a 13-million-member military during World War II, and overseeing the atomic bomb program.

Pick your favorite in our polls below, and check back each day to see a new Presidential Madness vote!

Note: If you can?t see the poll above, use this link:? http://poll.fm/45wld

Round 4: Secretary of defense (post-WWII)

The Defense Department grew out of World War II; its leaders had to manage a complex, global military force.

1. Melvin Laird. Served 1969?? 1973. A former congressman, Laird served under Richard Nixon, supervised the winding down of the Vietnam War, and ended the draft.

2. Caspar Weinberger. Served 1981 ? 1987. Weinberger lead the Defense Department for Ronald Reagan and oversaw a massive effort to build up the military as the Soviet Union crumbled.

3. Donald Rumsfeld. Served 1975 ? 1977, 2001 ? 2006. He first led the military under Gerald Ford and returned to the Defense Department to head the post-9/11 efforts in Afghanistan and Iraq.

4. Robert Gates. Served 2006?? 2011. Having served under both George W. Bush and Barack Obama, Gates was known for his bipartisan leadership and broad government and academic background.

Note: If you can?t see the poll above, use this link:?http://poll.fm/45wli

Also Read

Source: http://news.yahoo.com/presidential-madness-rounds-3-4-secretary-war-defense-102606637--politics.html

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Tuesday, March 26, 2013

Docomo Inks Deal With China Mobile To Take Its 'D Game' Gaming ...

NTT Docomo, the largest carrier in Japan, is taking one more step into China today. The company announced that it will offer a localized version of its new ?d game? gaming service on China Mobile. This will be the first time that d game is being exported to any market outside of Japan. Financial terms of the deal were not disclosed. The service will go live on March 26, initially with 20 titles.

As Japan is one of the most mobile-saturated and mature markets for content anywhere in the world, China has huge potential as an emerging, neighboring market for NTT Docomo. Specifically, China Mobile is the world?s biggest operator with 700 million subscribers, so it makes sense that Docomo is increasingly forging partnerships and porting its products across the border.

The move follows other developments for Docomo in China, and specifically with China Mobile. At the end of February, the two carriers, along with KT, agreed on an international NFC roaming service ? meaning that NFC readers in devices sold by each company would work in the other markets, and on specific NFC-based services developed locally. At the same time they also agreed on a WiFi roaming deal.

What?s not clear is whether this latest development to export d game is connected in any way with Docomo?s JV with Baidu, created last year when Docomo invested $22.5 million in the operation to create mobile content for the Chinese market. Instead, this deal is being carried out by D2C China, a subsidiary of D2C, a joint venture between Docomo and advertising giant Dentsu.

The first rush of content will feature some 20 titles, including games but also non-game content including wallpapers and covering well-known publishers such as Capcom, Konami, Tecmo Koei, Square Enix and MTI. More content is coming down the line, Docomo notes. ?Going forward, DOCOMO intends to grow its global content business with a variety of content originally distributed through the company?s dmarket? portal in Japan, providing overseas customers with opportunities to enjoy high-quality mobile content from Japan,? Docomo writes in its statement.


NTT Docomo is Japan???s leading mobile communications company. The number of customers exceeds 50 million in Japan. docomo mainly provides phone, web (i-mode for mobile phones), and mail (i-mode mails, Short Mails, and SMS) services. Docomo???s parent company is NTT, Japan???s biggest telecommunications companies. In a strategic decision to put more emphasis on mobile phone operations, docomo was spun off in 1991 as a wholly self-owned subsidiary. The Japanese government is the top shareholder.

? Learn more

Source: http://techcrunch.com/2013/03/25/docomo-extends-reach-in-china-with-d-game-gaming-portal-deal-on-china-mobile/

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Cyprus reaches 'painful' solution to secure rescue

Protesters hold a banner during an anti- bailout rally outside of European Union house in capital Nicosia, Cyprus, Sunday, March 24, 2013. After failing for a week to find a solution to a crisis that could force their country into bankruptcy, Cypriot politicians turned to the European Union on Sunday in a last-ditch effort to help the island nation forge a viable plan to secure an international bailout. (AP Photo/Petros Karadjias)

Protesters hold a banner during an anti- bailout rally outside of European Union house in capital Nicosia, Cyprus, Sunday, March 24, 2013. After failing for a week to find a solution to a crisis that could force their country into bankruptcy, Cypriot politicians turned to the European Union on Sunday in a last-ditch effort to help the island nation forge a viable plan to secure an international bailout. (AP Photo/Petros Karadjias)

From left, French Finance Minister Pierre Moscovici, Managing Director of the International Monetary Fund Christine Lagarde and German Finance Minister Wolfgang Schaeuble speak with each other during an emergency eurogroup meeting in Brussels on Sunday, March 24, 2013. The EU says a top official will chair a high-level meeting on Cyprus in a last-ditch effort to seal a deal before finance ministers decide whether the island nation gets a 10 billion euro bailout loan to save it from bankruptcy. (AP Photo/Geert Vanden Wijngaert)

A protestor waves a Cyprus flag in front of riot policemen during an anti-bailout rally outside of European Union house in Nicosia, Cyprus, Sunday, March 24, 2013. After failing for a week to find a solution to a crisis that could force their country into bankruptcy, Cypriot politicians turned to the European Union on Sunday in a last-ditch effort to help the island nation forge a viable plan to secure an international bailout. (AP Photo/Petros Karadjias)

A protestor holds a banner as he takes part in an anti- bailout rally outside of European Union house in Nicosia, Cyprus, Sunday, March 24, 2013. After failing for a week to find a solution to a crisis that could force their country into bankruptcy, Cypriot politicians turned to the European Union on Sunday in a last-ditch effort to help the island nation forge a viable plan to secure an international bailout. (AP Photo/Petros Karadjias)

Personnel carry in boxes of pizza to the European Council building as an emergency eurogroup meeting takes place in Brussels on Sunday, March 24, 2013. The EU says a top official will chair a high-level meeting on Cyprus in a last-ditch effort to seal a deal before finance ministers decide whether the island nation gets a 10 billion euro bailout loan to save it from bankruptcy. (AP Photo/Virginia Mayo)

(AP) ? Cyprus clinched a last-minute solution to avert imminent financial meltdown early Monday after it agreed to slash its oversized banking sector and inflict hefty losses on wealthy depositors in troubled banks to secure a 10 billion euro ($13 billion) bailout.

The deal, described by the country's politicians as "painful", was agreed with euro finance ministers in Brussels just in time. The European Central Bank had threatened to cut off crucial emergency assistance to the Cyprus's embattled banks after Monday if no agreement was reached.

Without that funding, Cyprus's banks would have collapsed, dragging the country's economy down with them and threatening the small Mediterranean island's membership of the 17-strong group of European Union countries that use the euro ? all of which would have sent the EU's markets spinning.

"It's not that we won a battle, but we really have avoided a disastrous exit from the eurozone," Finance Minister Michalis Sarris said in Brussels.

Markets in Europe reacted positively, opening sharply higher, and the euro was back near $1.30.

The mood in Nicosia was more somber, however.

"This decision is painful for the Cypriot people. This decision was a defeat of solidarity, of social cohesion, which are fundamental freedoms, fundamental principles of the European Union," Parliament President Yiannakis Omirou told AP.

"So as soon as possible we have to prepare our economy to go out from the mechanism and the troika," he said, referring to the bailout agreement and the three-member delegation from the European Commission, International Monetary Fund and ECB who oversee implementation of bailout measures.

Banks in Cyrpus have been closed for more than a week in Cyprus while politicians wrangled on how to raise 5.8 billion euros ($7.5 billion) to qualify for the rescue. An alternative was needed after the country's lawmakers resoundingly defeated the initial plan which would have seized up to 10 percent of funds in people's accounts in all banks.

While cash has been available through ATMs, many machines have quickly run out. Daily withdrawal limits of 100 euros were imposed on ATMs of country's two troubled lenders, Laiki and Bank of Cyprus, on Sunday. All banks are scheduled to reopen Tuesday.

Under the new plan, the bulk of the funds will be raised by forcing losses on wealthy savers in two of the country's banks, with the remainder coming from tax increases and privatizations.

Laiki, the country's second-largest bank, will be restructured, with all bond-holders and people with more than 100,000 euros in their accounts facing significant losses. The bank will be dissolved immediately into a bad bank containing its uninsured deposits and toxic assets, with the guaranteed deposits being transferred to the nation's biggest lender, Bank of Cyprus.

Deposits at Bank of Cyprus above the 100,000 euro insured level will be frozen until it becomes clear whether or to what extent they will also be forced to take losses. The money from those deposits will eventually be converted into bank shares. German Finance Minister Wolfgang Schaeuble said he expected a bit more than 50 percent of savings at Bank of Cyprus will be involved in the swap.

It is not yet clear how severe the losses would be to Laiki's large bank deposit holders, but the euro finance ministers noted the restructure expected to yield 4.2 billion euros overall. Analysts have estimated investors might lose up to 40 percent of their money.

The plan agreed Monday does not need extra approval from Cyprus's parliament because the losses are part of a restructuring of the island's banks ? which would come under legislation passed last week ? and not a tax.

To further secure Cyprus's economy, the size of the country's banking sector ? worth up to eight times the country's gross domestic product of about 18 billion euros? must also be drastically reduced , said Jeroen Dijsselbloem, who chairs the meetings of the eurozone's finance ministers.

The international creditors also said the country's business model of attracting foreign investors, including many Russians, with low taxes and lax financial regulation had backfired and needed to be reformed. The country would also have to cut its budget, implement structural reforms and privatize state assets.

Russia's prime minister on Monday slammed the deal, saying the agreement was tantamount to theft: "In my opinion, the stealing of what has been stolen continues there."

Moscow has been worried about the crisis in Cyprus with Russian citizens holding as much as 20 billion euros ($26 billion) in Cypriot banks.

Russian Deputy Prime Minister Igor Shuvalov also expressed concerns over the impact of Monday's decision.

"Despite all the assurances that we're receiving from the European Commission we fear that this (decision) could affect the stability of the euro, the stability of the eurozone and would send shockwaves to deteriorate the situation on the whole," he said.

Germany's Schaeuble, however, rejected the idea that the deal was a defeat for European solidarity.

"Cyprus is in a serious crisis, it needs help; Cyprus is getting that help," he said. "Europe is showing solidarity, Europe continues to show solidarity, but aid only makes sense and is only responsible when it overcomes the causes that lead to such crises."

He insisted that the deal was "the best possible way for Cyprus out of this crisis ... but it still is not a comfortable way."

Several national parliaments in eurozone countries such as Germany must approve the deal, which might take another few weeks. EU officials said they expect the whole program to be approved by mid-April.

Cyprus has been shut out of international markets for almost two years. It first applied for a bailout to recapitalize its ailing lenders and keep state finances afloat last June, but negotiations stalled. The uncertainty around the tiny nation of about 800,000 had shaken the entire eurozone of 300 million people, even though Cyprus only makes up less than 0.2 percent of the eurozone's economy.

The new measures are likely to deepen the recession in Cyprus.

"Nobody doubts that the Eurogroup decision and the agreement for our country's loans from the troika is a very painful agreement," said Nicholas Papadopoulos, head of Parliament's finance committee. "The consequences for the Cypriot economy and the daily lives of all the citizens will be seen in practice."

____

Geir Moulson in Berlin, Don Melvin and Juergen Baetz in Brussels, Pan Pylas in London and Nataliya Vasilyeva in Moscow contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-25-Cyprus-Financial%20Crisis/id-ad2a8decb1b94c4bb63a0cf990287557

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Thursday, March 21, 2013

Researchers link cancer to failures in chromosome protection for the first time

Wednesday, March 20, 2013

A study published today in the journal Nature Genetics explores a new mechanism that may contribute to the development of several tumours, including Chronic Lymphocytic Leukaemia, a type of cancer that affects more than a thousand new patients in Spain each year.

This work, led by researchers Carlos L?pez-Ot?n, from the University Institute of Oncology at the University of Oviedo; El?as Campo, from the Hospital Cl?nic/University of Barcelona; and Mar?a Blasco, the Director of the Spanish National Cancer Research Centre (CNIO), represents a significant milestone for the Spanish Consortium in the study of the Chronic Lymphocytic Leukaemia Genome.

"Chronic Lymphocytic Leukaemia is the most frequent leukaemia in Western countries," says L?pez-Ot?n, adding that, "Once the most frequent genetic and epigenetic changes in its development have been decoded, it's necessary to discover the biochemical mechanisms altered by those changes, in order to be able to improve the diagnosis and treatment of this disease."

Thus, continuing the work from previous studies led by Campo and L?pez-Ot?n published in Nature and Nature Genetics over the past two years, the researchers concentrated on the mutations affecting POT1, one of the genes involved in the protection of the ends of chromosomes, the telomeres.

This is the first time that a gene with this function has appeared mutated in a human cancer. Blasco says: "We have been studying telomere biology for a long time, given that alterations in telomere maintenance are associated with cancer and ageing. Although the mechanisms used by tumour cells to alter their telomeres have been identified, POT1 mutations reveal yet another, previously unknown route."

Each chromosome has, at its extremes, in its telomeres, a protective hood made up of proteins, and POT1 is the staple that fixes it in place, joining it to the telomeric DNA. All of the mutations discovered in POT1 prevent this gene from fulfilling its function. The DNA at the end of the chromosome is therefore left without its protective cover. The study of the biochemical pathway that leads from these abnormalities to the uncontrolled growth of B lymphocytes can provide important clues for the understanding of chronic lymphocytic leukaemia and cancer in general.

ONE OF THE MOST FREQUENTLY MUTATED GENES IN LEUKAEMIA

Furthermore, after analysing the genome of 341 chronic lymphocytic leukaemia patients ?comparing for each case the genes from normal healthy cells with those of tumour cells?, researchers have discovered that POT1 is one of the most frequently mutated genes in this illness.

Prior results from the Spanish Consortium for the study of the Chronic Lymphocytic Leukaemia Genome had already shown that more than a thousand mutations are involved in this disease, and that each patient has a unique combination of hundreds of them. One of the most unexpected findings of the Consortium's studies is the wide genetic and molecular diversity of the disease. The different mutated genes identify relatively small subgroups of patients with diverse disease characteristics. In fact, the most frequently-repeated mutations are only present in 15% of patients. Despite that, identifying them represents a great advance, because it is a step towards the goal of personalised therapies, adapted to the genetic profile of each individual tumour.

In the study published today, the researchers have found that 3.5% of patients with chronic lymphocytic leukaemia show POT1 mutations, but this figure rises to 9% in a subgroup of patients suffering from an especially aggressive form of the disease. In this way, the study identifies POT1 as one of the most important genes for this disease.

As Campo concludes, "Patients with POT1 mutations belong to the group that has the worst prognosis. Therapeutic intervention affecting this pathway could, therefore, help treat a group of patients whose clinical outcome is currently very poor."

###

Centro Nacional de Investigaciones Oncologicas (CNIO): http://www.cnio.es

Thanks to Centro Nacional de Investigaciones Oncologicas (CNIO) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 62 time(s).

Source: http://www.labspaces.net/127376/Researchers_link_cancer_to_failures_in_chromosome_protection_for_the_first_time

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Check with Your Credit Union or Insurance Company for Big ...

Check with Your Credit Union or Insurance Company for Big Savings When Car Shopping Trying to get the best price on a new or used car is an uphill battle, but odds are you have some friends in your corner you didn't know about: Your credit union and your auto insurance provider.

You may already know to check with your credit union for financing on that new car, since their interest rates are likely lower than anything a bank or (heaven forbid) an auto dealer will offer you. However, credit unions also offer car buying and discount programs through selected auto dealerships that can cut hundreds?sometimes thousands?off of the sticker price of the car you want. Many car insurance providers, most notably USAA, participate in similar programs.

The folks at Kiplinger also note that select manufacturers offer discounts to credit unions and insurance companies, so sometimes it's best to start the search with the type of car you want to buy. They also suggest a free-to-join non-profit that can qualify you for a price cut. When we discussed online quoting as a way to get a good price, a few of you also mentioned that non-profits like AAA or CAA can also help you score a bargain. Hit the link below for a few more money-saving tips.

Little-Known Discounts for Car Buyers | Kiplinger

Photo by David Hilowitz.

Source: http://lifehacker.com/5991468/check-with-your-credit-union-or-insurance-company-for-big-savings-when-car-shopping

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Wednesday, March 20, 2013

Monster from the deep hits the surface

The page you are looking for has moved. Please go to the main EurekAlert! homepage to locate the section you are interested in and reset your bookmarks.

If you are looking for this week's current news releases, click on "Breaking News" once you reach the main EurekAlert! homepage. If you are a reporter looking for the embargoed news section, go to the main EurekAlert! homepage, log in with your username and password and then, from the main reporter homepage, click on "Embargoed News." If you are a PIO looking to submit a release, go to the main EurekAlert! homepage, log in with your username and password and then, from the main PIO homepage, click "Submit a Release."

Thank you.

Source: http://www.eurekalert.org/pub_releases/2013-03/uoc-mft031913.php

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A&T Aggies finally win an NCAA game, 73-72

DAYTON, Ohio (AP) ? After more than 30 years of trying, North Carolina A&T finally has an NCAA win.

To do it, the Aggies had to survive one last, harrowing, close call.

Substitute guard Jeremy Underwood tripled his average with 19 points, leading the Aggies (20-16) past resilient Liberty 73-72 on Tuesday at the First Four to win their first NCAA tournament game after nine losses.

The victory advanced the Aggies to a showdown with top-seeded Louisville (29-5) in Lexington, Ky., Thursday.

"It's been a long time," first-year Aggies coach Cy Alexander said.

It could have been pushed back even longer. The Flames (15-21) ? only the second team ever to make the NCAA tournament with 20 losses ? had a chance to win it in the final seconds.

John Caleb Sanders drove coast to coast and flipped up a left-handed layup in heavy congestion that just glanced off the glass.

"I knew he was going to go to the rim, and I just wanted to play off of him," A&T defensive star Austin Witter said. "I just tried to keep my hands back, and use my length to alter the shot. I believe I got a little piece of it, but I'm not really sure.

"I think I did just enough to get it off."

Sanders was trying to draw a foul as much as make the frantic shot.

"We've had a lot of late-game situations similar to that, and Coach (Dale Layer) has always said to take it to the rim," Sanders said. "They took away my right hand, so I went left and tried to get to the basket, and it just didn't fall for me."

Asked if he was fouled on the play, he hesitated and then said, "I don't know. It's hard to tell when you're in the midst of a game. They didn't call it. So it wasn't a foul."

A&T rebounded and, while Sanders rolled in pain on the baseline, began to celebrate a Cinderella season of its own. The Aggies had a losing record before starting play in the Mid-Eastern Athletic Conference tournament. Four wins later, they were back in the big dance, putting an end to a string of 15 consecutive losing seasons.

"We worked very, very hard over the last three years since I've been here," said Underwood, who came in averaging just over 6 points a game. "We always believed in ourselves; we never stopped believing in ourselves. We just kept working hard, and we pulled it out.

"It showed that hard work pays off."

Underwood was perfect from the field, hitting a career-best six field goals in six attempts. Bruce Beckford added 16 points and Lamont Middleton 14.

"We told the players don't worry about Louisville tonight," Alexander said. "Just relax and enjoy some basketball on TV. We'll let them worry about Louisville when we get to Lexington tomorrow."

Davon Marshall had 22 points and Sanders 21 for Liberty.

A&T has a glittering, if now faded, legacy. The Aggies made it to the NCAA tournament seven years in a row 1982-88, but had fallen on hard times. They piled up 15 consecutive losing seasons until their late hot streak this year in the conference tournament pushed them above .500.

They were headed nowhere just 12 days earlier, after a loss at home to Norfolk State in the regular-season finale dropped them to 15-16.

But they roared through the conference tournament, winning each of their first two games by double-figure margins, and then showed some poise down the stretch of the semifinal and final to win close games against Delaware State and Morgan State, respectively.

In the battle of 16 seeds, each team took turns going on runs.

Underwood made two shots then drove the lane and hit a lefty lay-up before Adrian Powell swished a 3 from the left corner for a 61-51 lead with under 9 minutes left.

Underwood hit two foul shots with 1:49 left for a 73-67 lead but Liberty wouldn't give up. Marshall threw in a 3 from the last inch of the corner with 1:32 left, then with 11.2 seconds left, he scored again on a baseline drive off an assist from Sanders to narrow the margin to a point.

With 7 seconds left, Middleton was fouled but missed the front end of the bonus situation, setting the stage for Sanders' wild race against the clock.

Only Coppin State, 16-20 in 2008, had as many losses as the Flames coming into the NCAA tournament. Amazingly, the Flames opened the season by losing their first eight games. Despite two players quitting the team during that discouraging period, others stuck it out and persevered.

Still, they were run out of their own gym in their final home game, 83-68 by VMI, to fall to 10-20 on the season.

But then came an incredible stroll through the Big South tournament including playing, and beating, both of the divisional winners. Their 87-76 upset of Charleston Southern in the conference title game on March 10 assured them of the Big South's automatic spot in the tournament.

"I've been around college basketball since 1976, as a player and a coach, and I've never experienced a year like this," Layer said. "The depths of this year were the most in those 37 years. And when guys overcome what they have overcome as 18- to 20-year-old kids ? wow, I'll take that."

But it's A&T that will move on.

Witter was reminded of the task ahead, that no No. 16 seed has ever beaten a No. 1 like Louisville. He made a face.

"That's just a statistic," he said. "We're still going to go out there and play hard, play our game, and no matter what, we're going to try to get the win."

___

Follow Rusty Miller on Twitter: http://www.twitter.com/rustymillerap

Source: http://news.yahoo.com/t-aggies-finally-win-ncaa-game-73-72-010409371--spt.html

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Friday, March 15, 2013

What questions will be answered by UFC 158?

The UFC heads back to Canada, the place that may as well be their home and native land with the many, rabid Canadian fans. What questions will be answered by the fights?

Can Nick Diaz back up his years of smack towards GSP? In April of 2010, I interviewed Diaz. It was a week or two after he, his brother and teammates started a melee at a Strikeforce fight on national television. He had plenty of challenges in front of him that didn't involve going to the UFC. But Diaz only wanted to talk about one opponent: Georges St-Pierre.

Now, after a loss to Carlos Condit and a suspension for using banned substances, Diaz is getting a chance to take on GSP. It's a fight he's pushed for years. Can he come through in the clutch?

Will Johny Hendricks look past this fight? After Hendricks knocked out Martin Kampmann, he was told by UFC president Dana White that he had the title shot. But then the UFC gave the shot to Diaz and put Hendricks on the same card. Now fighting Carlos Condit, will Hendricks have his mind on the title and the title on his mind, or will he take out Condit with a first-minute knockout, as he did in two of his last three bouts?

Can Nate Marquardt rebound from his loss? In the final Strikeforce event, Marquardt looked overmatched against Tarec Saffiedine. Just two months later, he's back in the cage against Jake Ellenberger, a wrestler with knockout power. Will Marquardt show that he belongs back with the UFC??

Who will keep their job? After UFC 157, White said the promotion has about 100 more athletes on their roster than they should. Every fighter is under pressure to perform well, be professional, pass their drug tests and not give the UFC a reason to cut them.

Have you made your picks yet? Pick a fight, go to Cagewriter's Facebook page and tell us who will win and why. Your picks may show up on Cagewriter.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/questions-answered-ufc-158-202414280--mma.html

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Reminder: We're live from Samsung Unpacked on Thursday night

Samsung Unpacked

In case you've been living under a rock the past couple weeks, Samsung's throwing a little party on Thursday night in Times Square, and we're here in New York to partake in the festivities. That giant "4" in the middle of all the signage isn't an accident, of course, and we're all expecting to see the Galaxy S4 be unveiled.

So be sure to be around at 7 p.m. EDT (that's 4 p.m. on the left coast) for the Android Central Galaxy S4 liveblog, Samsung's live stream, and the mountain of stories that are sure to come out of it.



Source: http://feedproxy.google.com/~r/androidcentral/~3/U107CO4Unno/story01.htm

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